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Extracellular breakdown of collagen by mice decidual cells. A cytochemical and ultrastructural study
Godosevicius Katz, Sima.
  • Godosevicius Katz, Sima; Federal University of São Paulo. School of Medicine. Department of Histology. São Paulo. BR
Biocell ; 29(3): 261-270, Aug.-Dec. 2005. ilus
Article in English | LILACS | ID: lil-633232
ABSTRACT
The interaction of antimesometrial decidual cells and collagen fibrils was studied by light microscopy and ultrastructural cytochemistry in fed and acutely fasted mice on days 9-11 of pregnancy. Fibrillar elements in the extracellular space consisted of collagen fibrils and filamentous aggregates (disintegrating collagen fibrils). Intracellular vacuoles exhibited typical collagen immersed in electron-translucent material (clear vacuoles) and faint cross-banded collagen immersed in electron-opaque material (dark vacuoles). Fibrillar elements showed extracellular acid phosphatase activity which was stronger in the region of mature decidua than in predecidual cells region in all animals; it was conspicuous in mature decidua of fasted animals. Intracellular acid phosphatase activity was observed in dark vacuoles and lysosomes, and was absent in clear vacuoles in all cells studied. Since acid phosphatase activity reflects the presence of lysosomal hydrolases in general, the results indicate that breakdown of extracellular collagen occurs by release of lysosomal enzymes by decidual cells and also by internalization of collagen for intracellular degradation in fed and fasted mice. Collagen breakdown may be part of the process of tissue remodeling in mature and predecidual regions, however, in mature decidua, collagen breakdown is enhanced and may therefore contribute to nutrition of the fetus, specially in acutely fasted mice.
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Full text: Available Index: LILACS (Americas) Main subject: Collagen / Decidua / Extracellular Matrix / Histocytochemistry Limits: Animals / Pregnancy Language: English Journal: Biocell Journal subject: C‚lulas Year: 2005 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Federal University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Collagen / Decidua / Extracellular Matrix / Histocytochemistry Limits: Animals / Pregnancy Language: English Journal: Biocell Journal subject: C‚lulas Year: 2005 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Federal University of São Paulo/BR