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Early malnutrition alters the effect of chlordiazepoxide on inhibitory avoidance
Braz. j. med. biol. res ; 21(5): 1033-6, 1988. tab
Article in English | LILACS | ID: lil-63607
RESUMO
In order to study the functional consequences of brain changes caused by early malnutrition, rats were fed a protein-deficient diet from birth until 49 days of age and a balanced diet from day 50 to day 70. The animals were submitted to a step-down inhibitory avoidance task and to the flinch-jump nociceptive test at 49 and 70 days of age. Malnourished rats showed longer step-down latencies and lower flinch and junp theresholds than eutrophic animals. Chlordiazepoxide (5 mg/Kg, ip) shortened step-down latency of well-nourished rats, whereas it failed to do so in malnourished rats. Since well-nourished animals also became resistant to chlordiazepoxide when tested with a higher shock intensity, generating avoidance latencies comparable to those of malnourished animals, we conclude that the drug resistance induced by malnutrition may be secondary to enhanced pain sensitivity and/or reactivity
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Index: LILACS (Americas) Main subject: Runaway Behavior / Nociceptors / Chlordiazepoxide / Protein-Energy Malnutrition Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1988 Type: Article

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Index: LILACS (Americas) Main subject: Runaway Behavior / Nociceptors / Chlordiazepoxide / Protein-Energy Malnutrition Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1988 Type: Article