Effect of metronidazole on the cell surface charge of Trichomonas vaginalis and Tritrichomonas foetus
Braz. j. med. biol. res
;
21(5): 1037-45, 1988. ilus, tab
Article
in English
| LILACS
| ID: lil-63608
RESUMO
1. The effect of metronidazole, a drug used in the treatment of trichomoniasis, on the surface chage of both Trichomonas vaginalis and Tritrichomonas foetus was analyzed by cell electrophoresis. 2. Incubation of the parasites under anaerobic conditions for 2 or 120 min in the presence of 2.0 microng/ml metronidazole, a concentration which inhibits cell growth by about 50%, led to a marked decrease in the net surface charge of the parasites. 3. The metronidazole analogue, 1-hydroxyethyl-2-methyl-1-4-inhibited protozoan growth but had no effect on met surface charge. 4. These observations indicate that, in addition to its effect on intracellular structure, cuch as hydrogenosomes, metronidazole alters the surface of trichomonads
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Index:
LILACS (Americas)
Main subject:
Trichomonas vaginalis
/
Tritrichomonas
/
Metronidazole
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1988
Type:
Article
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