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Therapeutic effectiveness of biosimilar standard interferon versus pegylated interferon for chronic hepatitis C genotypes 2 or 3
Vigani, Aline Gonzalez; Gonçales, Eduardo Sellan; Pavan, Maria Helena Postal; Genari, Flavia; Tozzo, Raquel; Lazarini, Maria Silvia Kroll; Fais, Viviane; Feltrin, Adriana; Gonçales, Neiva Sellan; Gonçales Jr, Fernando Lopes.
  • Vigani, Aline Gonzalez; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Gonçales, Eduardo Sellan; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Pavan, Maria Helena Postal; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Genari, Flavia; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Tozzo, Raquel; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Lazarini, Maria Silvia Kroll; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Fais, Viviane; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Feltrin, Adriana; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Gonçales, Neiva Sellan; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
  • Gonçales Jr, Fernando Lopes; Universidade Estadual de Campinas. Viral Hepatitis Study Group. Campinas. BR
Braz. j. infect. dis ; 16(3): 232-236, May-June 2012. ilus, tab
Article in English | LILACS | ID: lil-638555
ABSTRACT

BACKGROUND:

Pegylated interferon (Peg-IFN) and standard interferon (IFN) play a significant role in the treatment of hepatitis C virus (HCV) infection. Biosimilar standard IFN is widely available in Brazil for the treatment of HCV infection genotypes 2 or 3, but its efficacy compared to Peg-IFN is unknown.

OBJECTIVE:

To compare the sustained virological response (SVR) rates following treatment with biosimilar standard IFN plus ribavirin (RBV) versus Peg-IFN plus RBV in patients with HCV genotypes 2 or 3 infection.

METHODS:

A retrospective cohort study was conducted in patients with HCV genotypes 2 or 3 infection treated with biosimilar standard IFN plus RBV or with Peg-IFN plus RBV. SVR rates of the two treatments were compared.

RESULTS:

From January 2005 to December 2010, 172 patients with a mean age of 44 +/- 9.3 years were included. There were eight (4.7%) patients with HCV genotype 2 infections. One hundred fourteen (66.3%) were treated with biosimilar standard IFN plus RBV, whist 58 (33.7%) patients were treated with Peg-IFN plus RBV. Between the two groups, there were no significant differences regarding age, gender, glucose level, platelet count, hepatic necroinflammatory grade, and hepatic fibrosis stage. Overall, 59.3% (102/172) patients had SVR. In patients treated with Peg-IFN plus RBV, 79.3% (46/58) had SVR compared to 49.1% (56/114) among those treated with biosimilar standard IFN plus RBV (p = 0.0001).

CONCLUSION:

In patients with HCV genotypes 2 or 3 infection, a higher SVR was observed in patients receiving Peg-IFN plus RBV related to patients treated with biosimilar standard IFN plus RBV.
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Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Polyethylene Glycols / Ribavirin / Interferons / Interferon-alpha / Hepacivirus / Hepatitis C, Chronic Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Polyethylene Glycols / Ribavirin / Interferons / Interferon-alpha / Hepacivirus / Hepatitis C, Chronic Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR