Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study / Tratamento de hipotiroidismo primário com doses semanais de levotiroxina: um estudo randomizado, unicego, crossover
Arq. bras. endocrinol. metab
;
56(4): 250-258, June 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-640700
ABSTRACT
OBJECTIVE:
Compliance to levothyroxine treatment in hypothyroidism is compromised by daily schedule, and a weekly dose may be an alternative. SUBJECTS ANDMETHODS:
This was a randomized, crossover study. Fourteen females were assigned to daily or weekly doses of LT4. After six weeks, they switched regimens. Thyroid parameters were measured at baseline, and after 42 and 84 days. Echocardiogram and hyperthyroidism symptoms were evaluated before and four hours after LT4 intake.RESULTS:
In the weekly dose treatment, fT4 levels were higher after taking LT4, and lower seven days after the last dose; by the 6th week there was a small decrease in T3 levels. TSH remained unchanged and there were no hyperthyroidism symptoms or echocardiographic manifestations.CONCLUSION:
Weekly dose leads to transient increases in fT4, without hyperthyroidism or cardiac symptoms. That approach seems to be a safe alternative for the treatment of hypothyroidism.RESUMO
OBJETIVO:
Aderência ao tratamento do hipotiroidismo é comprometido pelo uso diário de levotiroxina, e doses semanais poderiam ser uma alternativa. SUJEITOS EMÉTODOS:
Este é um estudo randomizado, crossover. Quatorze mulheres foram selecionadas para receber LT4 diariamente ou semanalmente. Após seis semanas, houve inversão do regime de tratamento. Avaliações tireoideanas foram realizadas antes, após 42 e 84 dias. Avaliação de sintomas de hipertireoidismo e ecocardiograma foi realizada antes e após quatro horas de LT4.RESULTADOS:
Com dose semanal, os níveis de fT4 foram mais elevados logo após a dose de LT4, e menores após sete dias; após seis semanas, houve diminuição de T3. TSH permaneceu inalterado e não houve manifestações ecocardiográficas ou de hipertireodismo.CONCLUSÃO:
Dose semanal de LT4 leva à elevação de fT4, sem manifestações de hipertireoidismo, e parece ser uma alternativa segura para o tratamento do hipotireoidismo.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Thyroxine
/
Hypothyroidism
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Arq. bras. endocrinol. metab
Journal subject:
Endocrinology
/
Metabolism
Year:
2012
Type:
Article
Affiliation country:
Australia
/
Brazil
Institution/Affiliation country:
Australian National University/AU
/
Universidade Federal do Paraná/BR
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