Bronquiolite associada à exposição a aroma artificial de manteiga em trabalhadores de uma fábrica de biscoitos no Brasil / Bronchiolitis associated with exposure to artificial butter flavoring in workers at a cookie factory in Brazil
J. bras. pneumol
;
38(3): 395-399, maio-jun. 2012. ilus, tab
Article
in Portuguese
| LILACS
| ID: lil-640764
RESUMO
OBJETIVO:
Relatar quatro casos de bronquiolite decorrente de exposição a aroma artificial de manteiga em uma fábrica de biscoitos no Brasil.MÉTODOS:
Descrevemos os achados clínicos, espirométricos e tomográficos nos quatro pacientes, assim como achados de biópsia pulmonar em um dos pacientes.RESULTADOS:
Os quatro pacientes eram homens jovens, não fumantes, e desenvolveram obstrução persistente ao fluxo aéreo (relação VEF1/CVF reduzida e VEF1 de 25-44% do previsto) após 1-3 anos de exposição a diacetil, sem a utilização de equipamentos de proteção individual, em uma fábrica de biscoitos. A TCAR mostrou achados indicativos de bronquiolite. Em um paciente, a biópsia pulmonar cirúrgica mostrou bronquiolite obliterante associada a células gigantes.CONCLUSÕES:
A bronquiolite decorrente de exposição a flavorizantes artificiais deve ser considerada em trabalhadores com obstrução ao fluxo aéreo no Brasil.ABSTRACT
OBJECTIVE:
To report the cases of four patients with bronchiolitis caused by exposure to artificial butter flavoring at a cookie factory in Brazil.METHODS:
We described the clinical, tomographic, and spirometric findings in the four patients, as well as the lung biopsy findings in one of the patients.RESULTS:
All four patients were young male nonsmokers and developed persistent airflow obstruction (reduced FEV1/FVC ratio and FEV1 at 25-44% of predicted) after 1-3 years of exposure to diacetyl, without the use of personal protective equipment, at a cookie factory. The HRCT findings were indicative of bronchiolitis. In one patient, the surgical lung biopsy revealed bronchiolitis obliterans accompanied by giant cells.CONCLUSIONS:
Bronchiolitis resulting from exposure to artificial flavoring agents should be included in the differential diagnosis of airflow obstruction in workers in Brazil.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Butter
/
Bronchiolitis
/
Food Industry
/
Occupational Exposure
/
Inhalation Exposure
/
Flavoring Agents
/
Occupational Diseases
Type of study:
Diagnostic study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
Portuguese
Journal:
J. bras. pneumol
Journal subject:
Pulmonary Disease (Specialty)
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Barão de Lucena/BR
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