Frequency of human platelet antigens in oncohematological patients with thrombocytopenia and the probability of incompatibility to platelet transfusions
Rev. bras. hematol. hemoter
;
34(3): 202-205, 2012. tab
Article
in English
| LILACS
| ID: lil-640868
ABSTRACT
OBJECTIVE:
The objective of this study was to evaluate the frequencies of human platelet antigens in oncohematological patients with thrombocytopenia and to analyze the probability of their incompatibility with platelet transfusions.METHODS:
Platelet antigen genotyping was performed by sequence-specific primer polymerase chain reaction (SSP-PCR) for the HPA-1a, HPA-1b, HPA-2a, HPA-2b, HPA-3a, HPA-3b, HPA-4a, HPA-4b, HPA-5a, HPA-5b; HPA-15a, HPA-15b alleles in 150 patients of the Hematology Service of the Hospital das Clínicas (FMUSP).RESULTS:
The allele frequencies found were HPA-1a 0.837; HPA-1b 0.163; HPA-2a 0.830; HPA-2b 0.170; HPA-3a 0.700; HPA-3b 0.300; HPA-4a 1; HPA-4b 0; HPA-5a 0.887; HPA-5b 0.113; HPA-15a 0.457 and HPA-15b 0.543.CONCLUSIONS:
Data from the present study showed that the A allele is more common in the population than the B allele, except for HPA-15. This suggests that patients homozygous for the B allele are more predisposed to present alloimmunization and refractoriness to platelet transfusions by immune causes. Platelet genotyping could be of great value in the diagnosis of alloimmune thrombocytopenia and to provide compatible platelet concentrates for these patients.
Full text:
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Index:
LILACS (Americas)
Main subject:
Blood Platelets
/
Antigens, Human Platelet
/
Platelet Transfusion
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Santo Amaro/BR
/
Universidade de São Paulo/BR
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