Short-term levosimendan treatment protects rat testes against oxidative stress
Braz. j. med. biol. res
;
45(8): 716-720, Aug. 2012. tab
Article
in English
| LILACS
| ID: lil-643659
ABSTRACT
The objective of this study was to evaluate the effect of short-term levosimendan exposure on oxidant/antioxidant status and trace element levels in the testes of rats under physiological conditions. Twenty male Wistar albino rats were randomly divided into two groups of 10 animals each. Group 1 was not exposed to levosimendan and served as control. Levosimendan (12 µg/kg) diluted in 10 mL 0.9% NaCl was administered intraperitoneally to group 2. Animals of both groups were sacrificed after 3 days and their testes were harvested for the determination of changes in tissue oxidant/antioxidant status and trace element levels. Tissue malondialdehyde (MDA) was significantly lower in the levosimendan group (P < 0.001) than in the untreated control group and superoxide dismutase and glutathione peroxidase (GSH-Px) levels were significantly higher in the levosimendan group (P < 0.001). Carbonic anhydrase, catalase and GSH levels were not significantly different from controls. Mg and Zn levels of testes were significantly higher (P < 0.001) and Co, Pb, Cd, Mn, and Cu were significantly lower (P < 0.001) in group 2 compared to group 1. Fe levels were similar for the two groups (P = 0.94). These results suggest that 3-day exposure to levosimendan induced a significant decrease in tissue MDA level, which is a lipid peroxidation product and an indicator of oxidative stress, and a significant increase in the activity of an important number of the enzymes that protect against oxidative stress in rat testes.
Full text:
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Index:
LILACS (Americas)
Main subject:
Pyridazines
/
Trace Elements
/
Reactive Oxygen Species
/
Oxidative Stress
/
Hydrazones
/
Malondialdehyde
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2012
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Bezmi Alem Foundation University Hospital/TR
/
The State Hospital of Mus/TR
/
Yüzüncü Yil University/TR
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