In vitro synergism of simvastatin and fluconazole against Candida species / Sinergismo in vitro de sinvastatina e fluconazol contra espécies de Candida
Rev. Inst. Med. Trop. Säo Paulo
;
54(4): 197-199, July-Aug. 2012. tab
Article
in English
| LILACS
| ID: lil-643950
ABSTRACT
Systemic fungal infections are responsible for high mortality rates. Several species of fungi may be involved, but Candida spp. is the most prevalent. Simvastatin is used to lower cholesterol and also exhibits antifungal action. The aim of this study was to evaluate the synergistic action of simvastatin with fluconazole against strains of Candida spp. Susceptibility testing was performed according to protocol M27-A3, by broth microdilution method and the synergistic effect of simvastatin and fluconazole was calculated based on FICI (Fractional Inhibitory Concentration Index). Eleven strains were evaluated, and simvastatin showed a synergistic effect with fluconazole against 10 (91%) of the Candida spp. strains tested. Simvastatin may be a valuable drug in the treatment of systemic infections caused by Candida spp.
RESUMO
Infecções fúngicas sistêmicas são responsáveis por altas taxas de mortalidade. Várias espécies de fungos podem estar envolvidas, mas Candida spp é a mais prevalente. A sinvastatina é usada para diminuir o colesterol e também exibe ação antifúngica. O objetivo deste estudo foi avaliar a ação sinérgica de sinvastatina e fluconazol contra cepas de Candida spp. O teste de susceptibilidade foi realizado de acordo com o protocolo M27-A3, pelo método de micro diluição em caldo e o efeito sinérgico de sinvastatina e fluconazol foi calculado com base no ICIF (Índice de Concentração Inibitória Fraccionada). Onze cepas foram avaliadas, e a sinvastatina mostrou um efeito sinérgico com o fluconazol em dez (91%) das cepas de Candida spp. Sinvastatina pode ser uma droga valiosa no tratamento de infecções sistêmicas causadas por Candida spp.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Candida
/
Fluconazole
/
Simvastatin
/
Antifungal Agents
Type of study:
Practice guideline
Limits:
Humans
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Ceará/BR
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