The importance of resveratrol in tissue aging: a review

ABSTRACT

Some theories point to the relationship between endocrinology and aging, while others support that agingis either linked to the immune system, or related to the thelomeres shortening and free radicals. However,what deserve the attention from the scientific community are the silent regulatory proteins 2 (Sir2). Theseproteins are dependent on Nicotinamide Adenin Dinucleodide (NAD+) and can be activated by either caloricrestriction or by a poliphenol, the resveratrol (3,5,4’-triidroxistilbene), also known as 3,5,4’stilbenetriol.Besides exerting benefits to health as a whole, resveratrol has been demonstrated to promote live extension.The resveratrol bring a diversity of benefits to health because they activate the same metabolic pathways asthose activated by the caloric restriction, demonstrating to be efficient to increase the lifespan. Moreover, itseems that the regulation of the mitochondrial biogenesis by the resveratrol is a potential therapeutic targetto deal with endothelial dysfunction and vascular diseases. In addition resveratrol could act as a prominentactivator of Sirt1 by amplifying the relationship NAD+/NADH, by increasing the expression of PGC-1 andby decreasing the expression of UCP2. A functional analysis of the resveratrol acting over the aging and thelife extension brings up the need for the investigation of multiple tissues by the fact that resveratrol could beassociated with the expression of genes in distinct metabolic functions that could be affected by aging.