Low protein diet during perinatal period decreasesthe number of subepicardial neurons in rats
Braz. j. morphol. sci
;
26(3/4): 181-185, July-Dec. 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-644176
ABSTRACT
Subepicardial plexus of the atria is an interdependent heart control system and its structure and functionmay be influenced by external factors. We studied the influence of protein deprivation on subepicardialneurons at early development stages by subjecting rats to a low protein diet (5% of casein) during pre and postnatal period. Atrial neurons were identified by histochemical methods b-nicotinamide adenine dinucleotide(NADH) reaction, b-nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) reaction andAcetylcholinesterase (AChE) reaction and counted in 21 day-old rats. Besides a significant reduction in bodyand heart weight, the total number of neurons decreased 46% in the undernourished group as compared tocontrol animals. Our data suggest that deficient nutrition during early developmental period may produceirreversible deleterious changes later in life.
Full text:
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Index:
LILACS (Americas)
Main subject:
Proteins
/
Embryonic Development
/
Neurons
Type of study:
Prognostic study
Limits:
Animals
/
Pregnancy
Language:
English
Journal:
Braz. j. morphol. sci
Journal subject:
Anatomy
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
São Judas Tadeu University/BR
/
University of São Paulo/BR
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