Your browser doesn't support javascript.
loading
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis / Solução oftálmica de azitromicina 1,5%: eficácia e modalidades de tratamento em blefarite crônica
Fadlallah, Ali; Rami, Hala El; Fahd, Daoud; Dunia, Ibrahim; Bejjani, Riad; Chlela, Elie; Waked, Naji; Jabbour, Elyse; Fahed, Sharbel.
  • Fadlallah, Ali; Lebanese American University. Department of Ophthalmology. Hamra. LB
  • Rami, Hala El; Lebanese American University. Department of Ophthalmology. Hamra. LB
  • Fahd, Daoud; Lebanese American University. Department of Ophthalmology. Hamra. LB
  • Dunia, Ibrahim; Lebanese American University. Department of Ophthalmology. Hamra. LB
  • Bejjani, Riad; Lebanese American University. Department of Ophthalmology. Hamra. LB
  • Chlela, Elie; Lebanese American University. Department of Ophthalmology. Hamra. LB
  • Waked, Naji; Lebanese American University. Department of Ophthalmology. Hamra. LB
  • Jabbour, Elyse; Lebanese American University. Department of Ophthalmology. Hamra. LB
  • Fahed, Sharbel; Lebanese American University. Department of Ophthalmology. Hamra. LB
Arq. bras. oftalmol ; 75(3): 178-182, maio-jun. 2012. ilus, tab
Article in English | LILACS | ID: lil-644444
ABSTRACT

PURPOSE:

To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities.

METHODS:

A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eye-friendly soap twice daily.

RESULTS:

Patients in both groups tolerated the treatment with minimal irritation. A significant improvement in signs and symptoms was noted at the one week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up.

CONCLUSION:

Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up.
RESUMO

OBJETIVO:

Avaliar a eficácia do uso tópico de azitromicina 1,5% no tratamento de blefarite crônica moderada a grave, comparando a eficácia de duas diferentes modalidades de tratamento.

MÉTODOS:

Um ensaio clínico randomizado incluiu 67 pacientes com blefarite anterior e/ou posterior crônica, acompanhados por três meses. Os sinais e sintomas foram classificados de acordo com a gravidade. Os pacientes foram randomizados em dois grupos 33 pacientes no grupo I e 34 pacientes no grupo II. Os pacientes do grupo I foram tratados com azitromicina tópica 1,5% duas vezes ao dia durante três dias, e os pacientes do grupo II foram tratados com azitromicina tópica 1,5% duas vezes ao dia durante três dias e, em seguida, ao deitar, durante o resto do mês. Todos os pacientes foram instruídos a aplicarem compressas quentes e higiene palpebral duas vezes ao dia.

RESULTADOS:

Os pacientes em ambos os grupos toleraram o tratamento com irritação mínima. Melhora significativa dos sinais e sintomas foi observada na visita de uma semana de acompanhamento. Grupo II mostrou uma melhora mais acentuada e mais duradoura que persistiu após três meses de acompanhamento.

CONCLUSÕES:

A solução de azitromicina oftálmica tópica 1,5% é uma opção eficaz de tratamento para a blefarite crônica. Em blefarite moderada a grave, o tratamento de um mês é seguro e demonstrou melhora acentuada em relação ao protocolo de três dias, sem recidiva significante até três meses de acompanhamento.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Ophthalmic Solutions / Blepharitis / Azithromycin / Anti-Bacterial Agents Type of study: Controlled clinical trial / Practice guideline / Observational study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2012 Type: Article Affiliation country: Lebanon Institution/Affiliation country: Lebanese American University/LB

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Ophthalmic Solutions / Blepharitis / Azithromycin / Anti-Bacterial Agents Type of study: Controlled clinical trial / Practice guideline / Observational study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2012 Type: Article Affiliation country: Lebanon Institution/Affiliation country: Lebanese American University/LB