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Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
Matos, Denise Cristina Souza; Marcovistz, Rugimar; Silva, Andréa Marques Vieira da; Quintilio, Wagner; Georgini, Ricardo Amaral.
  • Matos, Denise Cristina Souza; Fundação Instituto Oswaldo Cruz. Laboratório de Tecnologia Imunológica. Rio de Janeiro. BR
  • Marcovistz, Rugimar; Fundação Instituto Oswaldo Cruz. Laboratório de Tecnologia Imunológica. Rio de Janeiro. BR
  • Silva, Andréa Marques Vieira da; Fundação Instituto Oswaldo Cruz. Laboratório de Tecnologia Imunológica. Rio de Janeiro. BR
  • Quintilio, Wagner; Instituto Butantan. São Paulo. BR
  • Georgini, Ricardo Amaral; Instituto Butantan. São Paulo. BR
Braz. j. microbiol ; 43(2): 429-431, Apr.-June 2012. graf, tab
Article in English | LILACS | ID: lil-644455
ABSTRACT
The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production.
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Full text: Available Index: LILACS (Americas) Main subject: Bordetella pertussis / Whooping Cough / Enzyme Multiplied Immunoassay Technique / Diagnostic Techniques and Procedures Type of study: Diagnostic study Limits: Animals Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Instituto Oswaldo Cruz/BR / Instituto Butantan/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bordetella pertussis / Whooping Cough / Enzyme Multiplied Immunoassay Technique / Diagnostic Techniques and Procedures Type of study: Diagnostic study Limits: Animals Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Instituto Oswaldo Cruz/BR / Instituto Butantan/BR