Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition
Clinics
;
67(7): 761-765, July 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-645448
ABSTRACT
OBJECTIVE:
The association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients.METHOD:
R2* quantification was performed using renal blood oxygen level-dependent properties. Five healthy normotensive women (50±5.3 years) underwent magnetic resonance imaging in a 1.5T Signa Excite HDx scanner (GE Healthcare, Waukesha, WI). A multiple fast gradient-echo sequence was used to acquire R2*/T2* images (sixteen echoes from 2.1 ms/slice to 49.6 ms/slice in a single breath hold per location). The images were post-processed to generate R2* maps for quantification. Data were recorded before and at 30 minutes after the oral administration of an angiotensin II-converting enzyme inhibitor (captopril, 25 mg). The results were compared using an ANOVA for repeated measurements (mean + standard deviation) followed by the Tukey test. ClinicalTrials.gov NCT01545479.RESULTS:
A significant difference (p<0.001) in renal oxygenation (R2*) was observed in the cortex and medulla before and after captopril administration right kidney, cortex = 11.08 ± 0.56ms, medulla = 17.21 ± 1.47ms and cortex = 10.30 ± 0.44ms, medulla = 16.06 ± 1.74ms, respectively; and left kidney, cortex= 11.79 ± 1.85ms, medulla = 17.03 ± 0.88ms and cortex = 10.89 ± 0.91ms, medulla = 16.43 ± 1.49ms, respectively.CONCLUSIONS:
This result suggests that the technique efficiently measured alterations in renal blood oxygenation after angiotensin II-converting enzyme inhibition and that it may provide a new strategy for identifying the early stages of renal disease and perhaps new therapeutic targets.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Oxygen
/
Angiotensin-Converting Enzyme Inhibitors
/
Captopril
/
Kidney
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
FUC)+BR
/
MR Res Latin America GE Healthcare/BR
/
Servico de Investigação Diagnóstica (SIDI)/BR
/
Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)/BR
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