Interacción entre meropenem y ácido valproico: A propósito de dos casos pediátricos / Pharmacological interaction between meropenem and valproic acid: a report of two cases
Rev. chil. infectol
;
29(3): 353-355, jun. 2012.
Article
in Spanish
| LILACS
| ID: lil-645603
ABSTRACT
The pharmacological interaction between meropenem and valproic acid is potentially serious, especially in critically ill patients, resulting in low plasmatic levels of the anticonvulsant. However, to our knowledge, this interaction between meropenem and reduced valproic acid plasma levels has not been reported in the pediatric chilean population. We present two clinical cases of chilean children, thus reporting that this interaction is present in our population, with an aim at educating physicians about the possibility of such interaction.
RESUMEN
La interacción farmacológica entre meropenem y ácido valproico en pacientes críticos es potencialmente grave, reflejándose en una disminución del fármaco anticonvulsivante mayor a 70%. Se desconocen estrategias efectivas que la reviertan. Esta interacción no ha sido descrita en pacientes chilenos pediátricos. A través de la presentación de dos casos clínicos alertamos que la interacción puede suceder en nuestra población y educamos a los pediatras que indican meropenem sobre la posibilidad de este evento.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Seizures
/
Thienamycins
/
Valproic Acid
/
Beta-Lactamase Inhibitors
/
Anticonvulsants
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
Language:
Spanish
Journal:
Rev. chil. infectol
Journal subject:
Communicable Diseases
Year:
2012
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital de niños Dr. Exequiel González Cortés/CL
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