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Physical training prevents body weight gain but does not modify adipose tissue gene expression
Higa, T.S.; Bergamo, F.C.; Mazzucatto, F.; Fonseca-Alaniz, M.H.; Evangelista, F.S..
  • Higa, T.S.; Universidade de São Paulo. Escola de Artes, Ciências e Humanidades. São Paulo. BR
  • Bergamo, F.C.; Universidade de São Paulo. Escola de Educação Física e Esporte. São Paulo. BR
  • Mazzucatto, F.; Universidade de São Paulo. Escola de Artes, Ciências e Humanidades. São Paulo. BR
  • Fonseca-Alaniz, M.H.; Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina-LIM13. Instituto do Coração. São Paulo. BR
  • Evangelista, F.S.; Universidade de São Paulo. Escola de Artes, Ciências e Humanidades. São Paulo. BR
Braz. j. med. biol. res ; 45(10): 988-994, Oct. 2012. ilus, tab
Article in English | LILACS | ID: lil-647745
ABSTRACT
The relationship of body weight (BW) with white adipose tissue (WAT) mass and WAT gene expression pattern was investigated in mice submitted to physical training (PT). Adult male C57BL/6 mice were submitted to two 1.5-h daily swimming sessions (T, N = 18), 5 days/week for 4 weeks or maintained sedentary (S, N = 15). Citrate synthase activity increased significantly in the T group (P < 0.05). S mice had a substantial weight gain compared to T mice (4.06 ± 0.43 vs 0.38 ± 0.28 g, P < 0.01). WAT mass, adipocyte size, and the weights of gastrocnemius and soleus muscles, lung, kidney, and adrenal gland were not different. Liver and heart were larger and the spleen was smaller in T compared to S mice (P < 0.05). Food intake was higher in T than S mice (4.7 ± 0.2 vs 4.0 ± 0.3 g/animal, P < 0.05) but oxygen consumption at rest did not differ between groups. T animals showed higher serum leptin concentration compared to S animals (6.37 ± 0.5 vs 3.11 ± 0.12 ng/mL). WAT gene expression pattern obtained by transcription factor adipocyte determination and differentiation-dependent factor 1, fatty acid synthase, malic enzyme, hormone-sensitive lipase, adipocyte lipid binding protein, leptin, and adiponectin did not differ significantly between groups. Collectively, our results showed that PT prevents BW gain and maintains WAT mass due to an increase in food intake and unchanged resting metabolic rate. These responses are closely related to unchanged WAT gene expression patterns.
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Full text: Available Index: LILACS (Americas) Main subject: Physical Conditioning, Animal / Weight Gain / Gene Expression Regulation / Adipose Tissue, White Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Physical Conditioning, Animal / Weight Gain / Gene Expression Regulation / Adipose Tissue, White Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR