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The effects of angiotensin-converting enzyme inhibitors on peritoneal protein loss and solute transport in peritoneal dialysis patients
Basturk, Taner; Unsal, Abdulkadir; Koc, Yener; Nezaket, Eren; Ahbap, Elbis; Sakaci, Tamer; Sevinc, Mustafa.
  • Basturk, Taner; Sisli Etfal Research and Education Hospital. Department of Nephrology. Istanbul. TR
  • Unsal, Abdulkadir; Sisli Etfal Research and Education Hospital. Department of Nephrology. Istanbul. TR
  • Koc, Yener; Sisli Etfal Research and Education Hospital. Department of Nephrology. Istanbul. TR
  • Nezaket, Eren; Sisli Etfal Research and Education Hospital. Department of Biochemistry. Istanbul. TR
  • Ahbap, Elbis; Sisli Etfal Research and Education Hospital. Department of Nephrology. Istanbul. TR
  • Sakaci, Tamer; Sisli Etfal Research and Education Hospital. Department of Nephrology. Istanbul. TR
  • Sevinc, Mustafa; Sisli Etfal Research and Education Hospital. Department of Nephrology. Istanbul. TR
Clinics ; 67(8): 877-883, Aug. 2012. graf, tab
Article in English | LILACS | ID: lil-647789
ABSTRACT

OBJECTIVE:

The objective of this study was to examine the effects of angiotensin-converting enzyme inhibitors on peritoneal membrane transport, peritoneal protein loss, and proteinuria in peritoneal dialysis patients.

METHODS:

Fifty-four peritoneal dialysis patients were included in the study. The patients were divided into two groups. Group 1 (n = 34) was treated with angiotensin-converting enzyme inhibitors. Group 2 (n = 20) did not receive any antihypertensive drugs during the entire follow-up. Eleven patients were excluded from the study thereafter. Thus, a total of 30 patients in Group 1 and 13 patients in Group 2 completed the study. We observed the patients for six months. Group 1 patients received maximal doses of angiotensin-converting enzyme inhibitors for six months. Parameters at the beginning of study and at the end of six months were evaluated.

RESULTS:

At the end of six months, total peritoneal protein loss in 24-hour dialysate effluent was significantly decreased in Group 1, whereas it was increased in Group 2. Compared to the baseline level, peritoneal albumin loss in 24-hour dialysate effluent and 4-hour D/P creatinine were significantly increased in Group 2 but were not significantly changed in Group 1. A covariance analysis between the groups revealed a significant difference only in the decreased amount of total protein loss in 24-hour dialysate. Proteinuria was decreased significantly in Group 1.

CONCLUSION:

This study suggests that angiotensin-converting enzyme inhibitors reduce peritoneal protein loss and small-solute transport and effectively protect peritoneal membrane transport in peritoneal dialysis patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Peritoneum / Angiotensin-Converting Enzyme Inhibitors / Peritoneal Dialysis / Albumins Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2012 Type: Article Affiliation country: Turkey Institution/Affiliation country: Sisli Etfal Research and Education Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Peritoneum / Angiotensin-Converting Enzyme Inhibitors / Peritoneal Dialysis / Albumins Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2012 Type: Article Affiliation country: Turkey Institution/Affiliation country: Sisli Etfal Research and Education Hospital/TR