Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome
Rev. bras. hematol. hemoter
;
34(4): 280-284, 2012. tab
Article
in English
| LILACS
| ID: lil-648527
ABSTRACT
OBJECTIVE:
This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients.METHODS:
Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological methods (human leukocyte antigens Class I and Class II). A control group was obtained from the data of potential bone marrow donors registered in the Brazilian Bone Marrow Donor Registry (REDOME).RESULTS:
Positive associations with HLA-A25 and HLA-B18 were found for the b2a2 transcript, as well as a tendency towards a positive association with HLA-B40 and a negative association with HLA-A68. The b3a2 transcript showed positive associations with HLA-B40 and HLA-DRB1*3.CONCLUSION:
The negative association between human leukocyte antigens and the BCR-ABL transcript suggests that binding and presentation of peptides derived from the chimeric protein are effective to increase a cytotoxic T lymphocyte response appropriate for the destruction of leukemic cells.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Philadelphia Chromosome
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Leukemia
/
Leukemia, Myeloid
/
Genetic Predisposition to Disease
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
HLA Antigens
Type of study:
Risk factors
Limits:
Humans
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Santa Maria/BR
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