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Immune expression of E-cadherin and α, β and γ-Catenin adhesion molecules and prognosis for upper urinary tract urothelial carcinomas
Reis, Sabrina Thalita dos; Leite, Katia Ramos Moreira; Mosconi Neto, Alcides; Pontes Júnior, José; Viana, Nayara Izabel; Antunes, Alberto Azoubel; Dall'Oglio, Marcos Francisco; Srougi, Miguel.
  • Reis, Sabrina Thalita dos; University of Sao Paulo Medical School. Brazil and Instituto do Câncer do Estado de São Paulo. Urology Department. Laboratory of Medical Investigation.
  • Leite, Katia Ramos Moreira; University of Sao Paulo Medical School. Brazil and Instituto do Câncer do Estado de São Paulo. Urology Department. Laboratory of Medical Investigation.
  • Mosconi Neto, Alcides; University of Sao Paulo Medical School. Brazil and Instituto do Câncer do Estado de São Paulo. Urology Department. Laboratory of Medical Investigation.
  • Pontes Júnior, José; University of Sao Paulo Medical School. Brazil and Instituto do Câncer do Estado de São Paulo. Urology Department. Laboratory of Medical Investigation.
  • Viana, Nayara Izabel; University of Sao Paulo Medical School. Brazil and Instituto do Câncer do Estado de São Paulo. Urology Department. Laboratory of Medical Investigation.
  • Antunes, Alberto Azoubel; University of Sao Paulo Medical School. Brazil and Instituto do Câncer do Estado de São Paulo. Urology Department. Laboratory of Medical Investigation.
  • Dall'Oglio, Marcos Francisco; University of Sao Paulo Medical School. Brazil and Instituto do Câncer do Estado de São Paulo. Urology Department. Laboratory of Medical Investigation.
  • Srougi, Miguel; University of Sao Paulo Medical School. Brazil and Instituto do Câncer do Estado de São Paulo. Urology Department. Laboratory of Medical Investigation.
Int. braz. j. urol ; 38(4): 466-473, July-Aug. 2012. ilus, tab
Article in English | LILACS | ID: lil-649439
ABSTRACT

INTRODUCTION:

Cell adhesion molecules (CAM) are required for maintaining a normal epithelial phenotype, and abnormalities in CAM expression have been related to cancer progression, including bladder urothelial carcinomas. There is only one study that correlates E-cadherin and α-, β- and γ-catenin expression with prognosis of upper tract urothelial carcinomas. Our aim is to study the pattern of immune expression of these CAMs in urothelial carcinomas from the renal pelvis and ureter in patients who have been treated surgically. Our goal is to correlate these expression levels and characteristics with well-known prognostic parameters for disease-free survival. MATERIALS AND

METHODS:

We evaluated specimens from 20 patients with urothelial carcinomas of the renal pelvis and ureter who were treated with nephroureterectomy or ureterectomy between June 1997 and January 2007. CAM expression was evaluated by immunohistochemistry in a tissue microarray and correlated with histopathological characteristics and patient outcomes after a mean follow-up of 55 months.

RESULTS:

We observed a relationship between E-cadherin expression and disease recurrence. Disease recurrence occurred in 87.5% of patients with strong E-cadherin expression. Only 50.0% of patients with moderate expression and 0% of patients with weak or no expression of E-cadherin had disease recurrence (p = 0.014). There was also a difference in disease-free survival. Patients with strong E-cadherin expression had a mean disease-free survival rate of 49.1 months, compared to 83.9 months for patients with moderate expression (p = 0.011). Additionally, an absence of α-catenin expression was associated with tumors that were larger than 3 cm (p = 0.003).

CONCLUSIONS:

We demonstrated for the first time that immune expression of E-cadherin is related to tumor recurrence and disease-free survival rates, and the absence of α-catenin expression is related to tumor size in upper tract urothelial carcinomas.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Ureteral Neoplasms / Urinary Tract / Carcinoma / Biomarkers, Tumor / Cadherins / Catenins Type of study: Prognostic study Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2012 Type: Article Affiliation country: Brazil

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Full text: Available Index: LILACS (Americas) Main subject: Ureteral Neoplasms / Urinary Tract / Carcinoma / Biomarkers, Tumor / Cadherins / Catenins Type of study: Prognostic study Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2012 Type: Article Affiliation country: Brazil