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Relação entre níveis de fenilalanina, inteligência e condição socioeconômica de pacientes com fenilcetonúria / Relationships between phenylalanine levels, intelligence and socioeconomic status of patients with phenylketonuria
Castro, Isabel Pimenta Spínola; Borges, Juliana Martins; Chagas, Heloísa Alves; Tibúrcio, Jacqueline; Starling, Ana Lúcia Pimenta; Aguiar, Marcos José Burle de.
  • Castro, Isabel Pimenta Spínola; s.af
  • Borges, Juliana Martins; s.af
  • Chagas, Heloísa Alves; s.af
  • Tibúrcio, Jacqueline; s.af
  • Starling, Ana Lúcia Pimenta; s.af
  • Aguiar, Marcos José Burle de; s.af
J. pediatr. (Rio J.) ; 88(4): 353-356, jul.-ago. 2012. tab
Article in Portuguese | LILACS | ID: lil-649467
RESUMO

OBJETIVOS:

Avaliar inteligência e relação com concentrações sanguíneas de fenilalanina e condição socioeconômica de fenilcetonúricos entre 6 e 12 anos em tratamento.

MÉTODOS:

Sessenta e três crianças, classificadas por níveis de fenilalanina e condição socioeconômica, realizaram Wechsler Intelligence Scale for Children. Utilizou-se o programa Statistical Package for the Social Sciences (SPSS) para analisar níveis de fenilalanina; testes ANOVA para avaliar quociente de inteligência (QI) e níveis de fenilalanina; e regressão logística ordinal para avaliar chances de melhor desempenho em QI.

RESULTADOS:

Classificaram-se entre limítrofe e nível muito superior em QI total, 90,5% das crianças; em QI verbal, 96,8%; em QI de execução, 92,1%. Tiveram avaliação socioeconômica entre níveis baixo e médio superior, 98,4% das famílias. As chances de apresentar QI superior e médio foram 4,29 vezes maiores nas crianças com controle adequado e 4,03 vezes maiores nas de níveis socioeconômicos melhores.

CONCLUSÕES:

O tratamento preveniu o retardo mental em 90,5% dos pacientes. O controle dos níveis de fenilalanina e melhor nível socioeconômico se associaram aos melhores desempenhos em QI.
ABSTRACT

OBJECTIVES:

To assess intelligence and its relationship with blood phenylalanine concentrations and socioeconomic status in patients with phenylketonuria after 6 to 12 years of treatment.

METHODS:

Sixty-three children were classified according to phenylalanine levels and socioeconomic status and assessed using the Wechsler Intelligence Scale for Children. The Statistical Package for the Social Sciences (SPSS) was used to analyze phenylalanine; ANOVA was used to analyze intelligence quotients (IQ) and phenylalanine levels; and ordinal logistic regression was used to analyze the likelihood of higher IQ.

RESULTS:

The overall IQ scores of 90.5% of the children were within a range from borderline intellectual deficiency to very high intelligence; for verbal IQ this proportion was 96.8% and 92.1% had performance IQ scores within this band. The categories from low to upper-medium socioeconomic status contained 98.4% of patients' families. The likelihood of having medium to high IQ was 4.29 times greater for children with good phenylalanine control and 4.03 greater for those from higher socioeconomic strata.

CONCLUSIONS:

Treatment prevented mental retardation in 90.5% of the patients. Control of phenylalanine levels and higher socioeconomic status were associated with higher IQ scores.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Phenylalanine / Phenylketonurias / Social Class / Intelligence Type of study: Prognostic study / Risk factors Limits: Child / Female / Humans Language: Portuguese Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2012 Type: Article

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Full text: Available Index: LILACS (Americas) Main subject: Phenylalanine / Phenylketonurias / Social Class / Intelligence Type of study: Prognostic study / Risk factors Limits: Child / Female / Humans Language: Portuguese Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2012 Type: Article