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Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features
Nabuco, Leticia Cancella; Mello, Francisco Campello do Amaral; Gomes, Selma de Andrade; Perez, Renata Mello; Soares, Jorge André Segadas; Coelho, Henrique Sérgio Moraes; Nogueira, Cristiane Alves Villela.
  • Nabuco, Leticia Cancella; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro. BR
  • Mello, Francisco Campello do Amaral; Fiocruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro. BR
  • Gomes, Selma de Andrade; Fiocruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro. BR
  • Perez, Renata Mello; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro. BR
  • Soares, Jorge André Segadas; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro. BR
  • Coelho, Henrique Sérgio Moraes; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro. BR
  • Nogueira, Cristiane Alves Villela; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 107(6): 758-789, set. 2012. tab
Article in English | LILACS | ID: lil-649495
ABSTRACT
Data concerning the relationship between hepatitis B virus (HBV) genotypes and liver histology are scarce. The aim of this study was to compare HBV non-B and non-C genotypes according to demographic features, clinical status, HBV-DNA levels and liver histology in Rio de Janeiro. One hundred twenty one consecutive chronic HBV-infected patients were enrolled during two-year period and data were prospectively collected. Sera were tested for HBV genotyping using restriction fragment length polymorphism. Liver biopsy was obtained from patients with either increased alanine aminotransferase (ALT) or HBV-DNA levels. Genotype A was the most common, found in 82 (68%) patients, followed by F in 19 (15%), D in 17 (14%), B in one (1%) and C in two (2%). There was no association between HBV genotypes A, D and F and gender (p = 0.37), age (p = 0.78), race (p = 0.22), mode of infection (p = 0.94), HB "e" antigen status (p = 0.37) and HBV-DNA levels (p = 0.47). The ALT levels were lower in genotype D (75%) compared with A (47%) and F (55%) (p = 0.05). Liver biopsy showed lower inflammation [histological activity index (HAI) = 4] and fibrosis (F) (= 0) scores in genotype D than in genotypes A (HAI = 5, p < 0.001; F = 2, p = 0.008) or F (HAI = 5, p = 0.009; F = 2, p = 0.01). Genotype A was the most prevalent in chronic HBV-infected patients and genotype D patients presented with less intense liver disease.
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Full text: Available Index: LILACS (Americas) Main subject: DNA, Viral / Hepatitis B virus / Hepatitis B, Chronic / Liver Cirrhosis Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR / Universidade Federal do Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: DNA, Viral / Hepatitis B virus / Hepatitis B, Chronic / Liver Cirrhosis Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR / Universidade Federal do Rio de Janeiro/BR