Distinct subcellular localization of tRNA-derived fragments in the infective metacyclic forms of Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
107(6): 816-819, set. 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-649500
ABSTRACT
Small non-coding RNAs derived from transfer RNAs have been identified as a broadly conserved prokaryotic and eukaryotic response to stress. Their presence coincides with changes in developmental state associated with gene expression regulation. In the epimastigote form of Trypanosoma cruzi, tRNA fragments localize to posterior cytoplasmic granules. In the infective metacyclic form of the parasite, we found tRNA-derived fragments to be abundant and evenly distributed within the cytoplasm. The fragments were not associated with polysomes, suggesting that the tRNA-derived fragments may not be directly involved in translation control in metacyclics.
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Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
RNA, Transfer
/
RNA, Protozoan
/
Cytoplasmic Granules
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2012
Type:
Article
Affiliation country:
Brazil
/
Uruguay
Institution/Affiliation country:
Fiocruz/BR
/
Institut Pasteur de Montevideo/UY
/
Universidade Federal do Paraná/BR
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