Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients
Mem. Inst. Oswaldo Cruz
;
107(6): 824-827, set. 2012. ilus, graf, tab
Article
in English
| LILACS
| ID: lil-649502
ABSTRACT
The retrovirus human T lymphotropic virus type 1 (HTLV-1) promotes spastic paraparesis, adult T cell leukaemia and other diseases. Recently, some human microRNAs (miRNAs) have been described as important factors in host-virus interactions. This study compared miRNA expression in control individuals, asymptomatic HTLV-1 carriers and HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis patients. The proviral load and Tax protein expression were measured in order to characterize the patients. hsa-miR-125b expression was significantly higher in patients than in controls (p = 0.0285) or in the HAM group (p = 0.0312). Therefore, our findings suggest that miR-125b expression can be used to elucidate the mechanisms of viral replication and pathogenic processes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Paraparesis, Tropical Spastic
/
Gene Products, tax
/
MicroRNAs
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2012
Type:
Article
/
Project document
Affiliation country:
Brazil
/
Japan
Institution/Affiliation country:
Fiocruz-Rondônia,/BR
/
Universidade de São Paulo/BR
/
University of the Ryukyus/JP
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