Atividade in vitro da tigeciclina frente aos isolados de Acinetobacter baumannii no Hospital Júlia Kubitschek da Fundação Hospitalar de Minas Gerais / In vitro activity of tigecycline against Acinetobacter baumannii isolates in Hospital Júlia Kubitschek of Minas Gerais Hospital Foundation
Rev. bras. anal. clin
;
43(3): 197-200, 2011. tab, graf
Article
in Portuguese
| LILACS
| ID: lil-651504
RESUMO
Acinetobacter baumannii, importante patógeno nosocomial, pode ser difícil de ser tratado devido à resistência a váriasclasses de antimicrobianos, evidenciando a necessidade do uso de drogas de novas classes terapêuticas para estes microorganismos. A tigeciclina, uma nova glicilciclina, tem um amplo espectro de ação, incluindo Acinetobacter baumannii. O objetivo deste estudo foi verificar a atividade da tigeciclina contra cepas de Acinetobacter baumannii isoladas entre setembro de 2008 a maio de 2009 de pacientes internados no Hospital Júlia Kubitschek. Os testes de sensibilidade pelo método de disco difusão foram realizados de acordo com metodologia padronizada pelo CLSI. Com relação ao perfil de resistência, foi observado que a maioria das cepas de Acinetobacter baumannii eram multirresistentes e a tigeciclina apresentou atividade in vitro contra todas estas cepas.
ABSTRACT
Acinetobacter baumannii, a nosocomial pathogen, can be problematic to treat due to resistance to multiple classes ofantibiotics, further highlighting the need for new therapeutic agents effective against this organism. Tigecycline, a novel glycylcycline, has a broad spectrum of activity which includes Acinetobacter baumannii. The aim of this study was to verify the tigecycline activity profile against A. baumannii isolated between September 2008- May 2009 from patients interned in Hospital Júlia Kubitschek. To perform the assay, disk diffusion susceptibility testing was performed according to the CLSI guidelines. Regarding the profile ofresistance, it was observed that the majority of the strains of Acinetobacter baumannii were multiresistant and tigecycline were active in vitro against all of this strains.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
In Vitro Techniques
/
Acinetobacter Infections
/
Drug Resistance, Microbial
/
Microbial Sensitivity Tests
/
Cross Infection
/
Acinetobacter baumannii
/
Disk Diffusion Antimicrobial Tests
/
Intensive Care Units
/
Antifungal Agents
Type of study:
Practice guideline
Limits:
Humans
Language:
Portuguese
Journal:
Rev. bras. anal. clin
Journal subject:
Pathology
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Hospitalar de Minas Gerais/BR
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