Macroscopic placental changes associated with fetal and maternal events in diabetes mellitus
Clinics
;
67(10): 1203-1208, Oct. 2012. tab
Article
in English
| LILACS
| ID: lil-653485
ABSTRACT
OBJECTIVES:
The current study sought to identify macroscopic placental changes associated with clinical conditions in women with or without diabetes and their newborns.METHODS:
The study population consisted of 62 pregnant women clinically diagnosed with diabetes and 62 healthy women (control group).RESULTS:
Among the subjects with diabetes, 43 women (69.3%) were diagnosed with gestational diabetes mellitus, 15 had diabetes mellitus I (24.2%), and four had diabetes mellitus II (6.5%). The mean age of the women studied was 28.5 ± 5.71 years, and the mean gestational age of the diabetic women was 38.51 weeks. Of the 62 placentas from diabetic pregnancies, 49 (79%) maternal surfaces and 59 (95.2%) fetal surfaces showed abnormalities, including calcium and fibrin deposits, placental infarction, hematoma, and fibrosis. A statistical association was found between newborn gender and fetal and maternal placental changes (p = 0.002). The mean weight of the newborns studied was 3,287 ± 563 g for women with diabetes mellitus, 3,205 ± 544 g for those with gestational diabetes mellitus, 3,563 ± 696 g forthose with diabetes mellitus II, and 3,095 ± 451 g forthose with diabetes mellitus I.CONCLUSIONS:
Infarction, hematoma, calcification, and fibrin were found on the maternal and fetal placental surfaces in women with diabetes. Women with gestational diabetes and post-term infants had more calcium deposits on the maternal placental surface as compared to those with type I and type II diabetes.
Full text:
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Index:
LILACS (Americas)
Main subject:
Placenta
/
Diabetes, Gestational
/
Diabetes Complications
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Goias Federal University/BR
/
Triângulo Mineiro Federal University/BR
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