The prevalence of human cytomegalovirus DNA in gliomas of Brazilian patients

Fonseca, Renata Fragelli; Kawamura, Marcia Tie; Oliveira, José Antônio; Teixeira, Anselmo; Alves, Gilda; Carvalho, Maria da Glória da Costa

Fonseca, Renata Fragelli; Kawamura, Marcia Tie; Oliveira, José Antônio; Teixeira, Anselmo; Alves, Gilda; Carvalho, Maria da Glória da Costa.

Fonseca, Renata Fragelli; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Controle da Expressão Gênica. Rio de Janeiro. BR
Kawamura, Marcia Tie; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Controle da Expressão Gênica. Rio de Janeiro. BR
Oliveira, José Antônio; Instituto Nacional de Câncer. Serviço de Neurocirurgia. Rio de Janeiro. BR
Teixeira, Anselmo; Instituto Nacional de Câncer. Serviço de Neurocirurgia. Rio de Janeiro. BR
Alves, Gilda; Instituto Nacional de Câncer. Serviço de Hematologia. Laboratório de Genética Aplicada. Rio de Janeiro. BR
Carvalho, Maria da Glória da Costa; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Controle da Expressão Gênica. Rio de Janeiro. BR

Mem. Inst. Oswaldo Cruz ; 107(7): 953-954, Nov. 2012. ilus, tab

Article in English | LILACS | ID: lil-656057

ABSTRACT

ABSTRACT

Members of the Herpesviridae family have been implicated in a number of tumours in humans. At least 75% of the human population has had contact with cytomegalovirus (HCMV). In this work, we screened 75 Brazilian glioma biopsies for the presence of HCMV DNA sequences. HCMV DNA was detected in 36% (27/75) of the biopsies. It is possible that HCMV could be a co-factor in the evolution of brain tumours.

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Adult; Child; Female; Humans; Male; Young Adult; Brain Neoplasms/virology; Cytomegalovirus Infections/complications; Cytomegalovirus/genetics; DNA, Viral/analysis; Glioma/virology; Biopsy; Cohort Studies; Cytomegalovirus Infections/diagnosis; Cytomegalovirus/immunology; Immediate-Early Proteins/analysis; Immediate-Early Proteins/immunology; Neoplasm Staging; Polymerase Chain Reaction; Prevalence

Brain tumour; Cytomegalovirus; Glioma; HCMV

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Full text: Available Index: LILACS (Americas) Main subject: Brain Neoplasms / DNA, Viral / Cytomegalovirus Infections / Cytomegalovirus / Glioma Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prevalence study / Risk factors Limits: Adult / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Nacional de Câncer/BR / Universidade Federal do Rio de Janeiro/BR

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