Antimicrobial activity of meta-alkoxyphenylcarbamates containing substituted N-phenylpiperazine fragment
Braz. j. microbiol
;
43(3): 959-965, July-Sept. 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-656659
ABSTRACT
In the present investigation, the basic esters of meta-alkoxyphenylcarbamic acid bearing variously substituted N-phenylpiperazine fragment were screened for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, respectively. The most effective against Escherichia coli was found the compound 6d (MIC=195,3 μg/mL) bearing simultaneously para-fluoro substituent at the 4‑phenylpiperazin-1-yl core and meta-methoxy side chain in the lipophilic part of the molecule. From whole analyzed set of the molecules the substance 8e with propoxy side chain forming meta-alkoxyphenylcarbamoyl fragment and lipophilic, sterically bulky meta-trifluoromethyl group attached at N-phenylpiperazine moiety was evaluated as the most active against Candida albicans (MIC=97,7 μg/mL). On the contrary, all investigated structures were practically inactive against Staphylococcus aureus (MIC>1000 μg/mL).
Full text:
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Index:
LILACS (Americas)
Main subject:
In Vitro Techniques
/
Candida albicans
/
Drug Resistance
/
Drug Resistance, Microbial
/
Genetic Predisposition to Disease
/
Escherichia coli
/
Anti-Bacterial Agents
Type of study:
Prevalence study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2012
Type:
Article
Affiliation country:
Slovakia
Institution/Affiliation country:
Comenius University/SK
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