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Demências rapidamente progressivas. Revisão atualizada e etapas diagnósticas / Rapidly progressive dementias. Updated review and diagnostic steps
Engelhardt, Eliasz.
  • Engelhardt, Eliasz; Universidade Federal do Rio de Janeiro. Instituto de Neurologia Deolindo Couto. Setor de Neurologia Cognitiva e do Comportamento. Rio de Janeiro. BR
Rev. bras. neurol ; 48(3): 25-41, jul.-set. 2012. tab
Article in Portuguese | LILACS | ID: lil-658450
RESUMO
As demências rapidamente progressivas (DRPs) constituem um grupo heterogêneo de condições clínicas (neurodegenerativas, vasculares, infecciosas, imunomediadas, tóxicas, metabólicas, tumorais, psicogênicas) e cirúrgicas. Suas principais características são início e evolução rápidos, com comprometimento cognitivo, comportamental, psicológico e motor. Avaliação detalhada é imprescindível, devendo ser seguido protocolo extenso, de modo sistematizado, compreendendo anamnese minuciosa, exames clínico e neurológico e complementares de sangue, urina, LCR, EEG, neuroimagem e eventualmente biópsia cerebral. A investigação deve ser rápida, já que podem ser encontradas causas reversíveis, e uma demora pode levar a morbidade ou mortalidade. As DRPs representam um desafio clínico complexo, mesmo para os profissionais mais experientes.
ABSTRACT
Rapidly progressive dementias (RPDs) constitute a heterogeneous group of clinical (neurodegenerative, vascular, infectious, immunomediated, toxic, metabolic, tumoral, psychogenic) and surgical conditions. Their main characteristic is rapid start and course with cognitive, behavioral, psychological and motor impairment. Detailed evaluation is essential, and an extensive protocol that must be followed in a systematic way, including a meticulous anamnesis, clinical and neurological examination, and complementary assessment, including blood, urine, CSF, EEG, neuroimaging exams, and eventually brain biopsy. The investigation must be fast, considering that reversible causes may be found, and a delay can lead to morbidity ou mortality. The RPDs represent a complex clinical challenge, even for the most experienced professionals.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Sensitivity and Specificity / Cognition Disorders / Disease Progression / Dementia / Neurologic Examination Type of study: Diagnostic study / Practice guideline Limits: Aged / Female / Humans / Male Language: Portuguese Journal: Rev. bras. neurol Journal subject: Neurology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Sensitivity and Specificity / Cognition Disorders / Disease Progression / Dementia / Neurologic Examination Type of study: Diagnostic study / Practice guideline Limits: Aged / Female / Humans / Male Language: Portuguese Journal: Rev. bras. neurol Journal subject: Neurology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio de Janeiro/BR