Stem cells: sources and therapies
Biol. Res
;
45(3): 207-214, 2012.
Article
in English
| LILACS
| ID: lil-659278
ABSTRACT
The historical, lexical and conceptual issues embedded in stem cell biology are reviewed from technical, ethical, philosophical, judicial, clinical, economic and biopolitical perspectives. The mechanisms assigning the simultaneous capacity to self-renew and to differentiate to stem cells (immortal template DNA and asymmetric division) are evaluated in the light of the niche hypothesis for the stemness state. The induction of cell pluripotency and the different stem cells sources are presented (embryonic, adult and cord blood). We highlight the embryonic and adult stem cell properties and possible therapies while we emphasize the particular scientific and social values of cord blood donation to set up cord blood banks. The current scientific and legal frameworks of cord blood banks are reviewed at an international level as well as allogenic, dedicated and autologous donations. The expectations and the challenges in relation to present-day targeted diseases like diabetes mellitus type I, Parkinson's disease and myocardial infarction are evaluated in the light of the cellular therapies for regenerative medicine.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Blood Banks
/
Stem Cell Transplantation
/
Adult Stem Cells
/
Embryonic Stem Cells
Limits:
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2012
Type:
Article
/
Project document
Affiliation country:
Italy
Institution/Affiliation country:
San Matteo Foundation for Research, Hospitalization and Health Care/IT
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