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Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
Alexandre, Kamilla Vêncio Frauzino; Martins, Regina Maria Bringel; Souza, Márcia Maria de; Rodrigues, Isolina Maria Xavier; Teles, Sheila Araujo.
  • Alexandre, Kamilla Vêncio Frauzino; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
  • Martins, Regina Maria Bringel; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
  • Souza, Márcia Maria de; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
  • Rodrigues, Isolina Maria Xavier; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
  • Teles, Sheila Araujo; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
Mem. Inst. Oswaldo Cruz ; 107(8): 1060-1063, Dec. 2012. graf
Article in English | LILACS | ID: lil-660656
ABSTRACT
The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (> 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.
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Full text: Available Index: LILACS (Americas) Main subject: Hepatitis B Vaccines / Hepatitis B / Hepatitis B Antibodies Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Child / Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Goiás/BR

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Full text: Available Index: LILACS (Americas) Main subject: Hepatitis B Vaccines / Hepatitis B / Hepatitis B Antibodies Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Child / Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Goiás/BR