Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
Mem. Inst. Oswaldo Cruz
;
107(8): 1060-1063, Dec. 2012. graf
Article
in English
| LILACS
| ID: lil-660656
ABSTRACT
The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (> 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hepatitis B Vaccines
/
Hepatitis B
/
Hepatitis B Antibodies
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Child
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Goiás/BR
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