The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
107(8): 1076-1079, Dec. 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-660661
ABSTRACT
To characterise the trypanosomatid-exclusive RNA-binding protein TcRBP19, we analysed the phenotypic changes caused by its overexpression. Although no evident changes were observed when TcRBP19 was ectopically expressed in epimastigotes, the metacyclogenesis process was affected. Notably, TcRBP19 overexpression also led to a decrease in the number of infected mammalian cells. These findings suggest that TcRBP19 may be involved in the life cycle progression of the Trypanosoma cruzi parasite.
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Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
Protozoan Proteins
/
RNA-Binding Proteins
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2012
Type:
Article
Affiliation country:
Uruguay
Institution/Affiliation country:
Facultad de Ciencias/UY
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