The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Acta cir. bras
;
28(1): 5-9, jan. 2013. ilus, tab
Article
in English
| LILACS
| ID: lil-662341
ABSTRACT
PURPOSE:
To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia.METHODS:
Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol.RESULTS:
Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury.CONCLUSION:
Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hydroxyethyl Starch Derivatives
/
Plasma Substitutes
/
Acute Kidney Injury
/
Ischemia
/
Isotonic Solutions
/
Kidney
Type of study:
Practice guideline
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
UNESP/BR
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