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Unripe Musa sapientum peel in the healing of surgical wounds in rats
Atzingen, Dênia Amélia Novato Castelli Von; Gragnani, Alfredo; Veiga, Daniela Francescato; Abla, Luis Eduardo Felipe; Cardoso, Lorraine Lorene Felix; Ricardo, Thiago; Mendonça, Adriana Rodrigues dos Anjos; Ferreira, Lydia Masako.
  • Atzingen, Dênia Amélia Novato Castelli Von; UNIFESP. Postgraduate Program in Plastic Surgery. Sao Paulo. BR
  • Gragnani, Alfredo; UNIFESP. Postgraduate Program in Plastic Surgery. Sao Paulo. BR
  • Veiga, Daniela Francescato; UNIFESP. Postgraduate Program in Plastic Surgery. Sao Paulo. BR
  • Abla, Luis Eduardo Felipe; UNIFESP. Postgraduate Program in Plastic Surgery. Sao Paulo. BR
  • Cardoso, Lorraine Lorene Felix; UNIFESP. Postgraduate Program in Plastic Surgery. Sao Paulo. BR
  • Ricardo, Thiago; UNIFESP. Postgraduate Program in Plastic Surgery. Sao Paulo. BR
  • Mendonça, Adriana Rodrigues dos Anjos; UNIFESP. Postgraduate Program in Plastic Surgery. Sao Paulo. BR
  • Ferreira, Lydia Masako; UNIFESP. Postgraduate Program in Plastic Surgery. Sao Paulo. BR
Acta cir. bras ; 28(1): 33-38, jan. 2013. ilus, tab
Article in English | LILACS | ID: lil-662345
ABSTRACT

PURPOSE:

To assess the effects of unripe Musa sapientum peel on the healing of surgical wounds in rats.

METHODS:

One hundred and twenty Wistar rats were divided into two treatment groups of 60 animals each the control group (gel without the active ingredient) and experimental group (4% Musa sapientum peel gel). A 4 x 4 cm surgical wound was created on the back of each animal. The wound was cleaned daily with 0.9% saline, treated with 4% gel or natrosol gel (control), and covered with gauze. Animals from both groups were sacrificed after seven, 14 and 21 days of treatment; the tissue from the wound site was removed together with a margin of normal skin for histological analysis.

RESULTS:

No significant differences in wound contraction rates (p=0.982) were found between time points (seven, 14 and 21 days of treatment) in both groups. However, a significantly higher wound contraction rate was observed in the control group on day 21 compared with the experimental group (p=0.029). There were no significant differences in histomorphological features between groups. The experimental group showed an increased number of polymorphonuclear cells on day 7, with a significant reduction on day 21 (p=0.026).

CONCLUSION:

The use of 4% unripe Musa sapientum peel gel on surgical wounds in rats resulted in an increased number of polymorphonuclear cells on day 7, reduced wound contraction, reduced vascular proliferation and increased concentration of collagen fibers on day 21.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Wound Healing / Plant Extracts / Musa / Gels / Phytotherapy Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: UNIFESP/BR

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Full text: Available Index: LILACS (Americas) Main subject: Wound Healing / Plant Extracts / Musa / Gels / Phytotherapy Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: UNIFESP/BR