Hyperbaric oxygen therapy and ischemia and reperfusion: a valuable association to attenuate ischemic lesion and hepatic reperfusion
Acta cir. bras
;
28(2): 126-130, Feb. 2013. graf
Article
in English
| LILACS
| ID: lil-662360
ABSTRACT
PURPOSE:
To investigate the consequences of the association between hyperbaric oxygen therapy and hepatic ischemia / reperfusion.METHODS:
Wistar rats were divided into three groups SHAM, rats submitted to surgical stress and anesthetic but not hepatic ischemia or reperfusion, I / R, rats submitted to total hepatic pedicle ischemia for 30 min, followed by 5 min of reperfusion; HBO120, rats submitted to 120 min of hyperbaric oxygen therapy at two absolute atmospheres and immediately after submitted to the experimental protocol of ischemia and reperfusion. The preservation of the hepatic function was evaluated by determining mitochondrial swelling and malondialdehyde tissue level, as well as alanine aminotransferase and aspartate aminotranferase serum levels. The results were analyzed using the Mann-Whitney test and differences were considered significant for p<0.05.RESULTS:
There were significant differences in values mitochondrial swelling of the I / R group compared to SHAM and HBO120; malondialdehyde between SHAM vs. I / R, SHAM vs HBO120, and I / R vs HBO120, alanine aminotransferase between SHAM vs. I / R . There was no significant difference between groups in aspartate aminotransferase serum levels.CONCLUSION:
The association between hyperbaric oxygen therapy and hepatic ischemia and reperfusion process was positive.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Reperfusion Injury
/
Hyperbaric Oxygenation
/
Ischemia
/
Liver
Type of study:
Practice guideline
/
Risk factors
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
FAMEMA/BR
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