A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury
Acta cir. bras
;
28(2): 154-159, Feb. 2013. ilus, graf
Article
in English
| LILACS
| ID: lil-662365
ABSTRACT
PURPOSE:
To investigate the protective effects of pentoxifylline against lung injury observed after dorsal scald in aged animals.METHODS:
Adult (eight months old) and aged (20 months old) rats were subjected to thermal injury or sham procedure. The six hours post-trauma animals received pentoxifylline and after 24 hours were euthanatized and lung tissue samples collectedted. The bronchoalveolar lavage fluid was evaluated for total protein content and tumor necrosis factor-alpha cytokine. Malondialdehyde and myeloperoxidase activety in the lung homogenate were measured and a histological lung examination was undertaken.RESULTS:
Burn injury induced oxidative stress in lung homogenate was higher in elderly-burned rats compared to adult-burned rats (p<0.001). Total protein and cytokine in bronchoalveolar lavage increased in the elderly-burned group when compared to the adult-burned group (p<0.001). All parameters decreased in bolth groups treated with pentoxifylline (p<0.05).CONCLUSIONS:
The injury was augmented in elderly rats when compared to adult rats. Damage was reduced with the use of pentoxifylline, however further studies are needed to evaluate the dose-response of the drug.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pentoxifylline
/
Free Radical Scavengers
/
Lung Injury
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
UNIFESP/BR
Similar
MEDLINE
...
LILACS
LIS