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Glioblastoma: approach to treat elderly patients / Glioblastoma: enfoque no tratamento de pacientes idosos
Pontes, Luciola de Barros; Karnakis, Theodora; Malheiros, Suzana Maria Fleury; Weltman, Eduardo; Brandt, Reynaldo André; Guendelmann, Rafael Aliosha Kaliks.
  • Pontes, Luciola de Barros; Hospital Israelita Albert Einstein. Department of Clinical Oncology. São Paulo. BR
  • Karnakis, Theodora; Hospital Israelita Albert Einstein. Department of Clinical Oncology. São Paulo. BR
  • Malheiros, Suzana Maria Fleury; Hospital Israelita Albert Einstein. Department of Clinical Oncology. São Paulo. BR
  • Weltman, Eduardo; Hospital Israelita Albert Einstein. Department of Clinical Oncology. São Paulo. BR
  • Brandt, Reynaldo André; Hospital Israelita Albert Einstein. Department of Clinical Oncology. São Paulo. BR
  • Guendelmann, Rafael Aliosha Kaliks; Hospital Israelita Albert Einstein. Department of Clinical Oncology. São Paulo. BR
Einstein (Säo Paulo) ; 10(4): 512-518, Oct.-Dec. 2012. tab
Article in English | LILACS | ID: lil-662480
ABSTRACT
Treating elderly cancer patients is a challenge for oncologists, especially considering the several therapeutic modalities in glioblastoma. Extensive tumor resection offers the best chance of local control. Adequate radiotherapy should always be given to elderly patients if they have undergone gross total resection and have maintained a good performance status. Rather than being ruled out, chemotherapy should be considered, and temozolomide is the chosen drug. A comprehensive geriatric assessment is a valuable tool to help guiding treatment decisions in elderly patients with glioblastoma.
RESUMO
O tratamento de idosos com câncer é um desafio para a prática oncológica, especialmente no que se refere à terapêutica multimodal do glioblastoma. Nessa população, a ressecção ampla do tumor oferece a melhor chance de controle local e, naqueles pacientes que mantenham um bom performance status, a radioterapia complementar deve sempre ser levada em consideração. A quimioterapia também tem um papel no tratamento, sendo a temozolomida a droga de eleição. Frente à heterogeneidade desses pacientes, uma avaliação geriátrica ampla é um instrumento valioso no auxílio da decisão terapêutica em idosos com glioblastoma.
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Full text: Available Index: LILACS (Americas) Main subject: Geriatric Assessment / Glioblastoma Type of study: Prognostic study Limits: Aged / Humans Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Israelita Albert Einstein/BR

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Full text: Available Index: LILACS (Americas) Main subject: Geriatric Assessment / Glioblastoma Type of study: Prognostic study Limits: Aged / Humans Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2012 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Israelita Albert Einstein/BR