The influence of hydroxyurea on oxidative stress in sickle cell anemia
Rev. bras. hematol. hemoter
;
34(6): 421-425, 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-662717
ABSTRACT
OBJECTIVE:
The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any hemoglobinopathy.METHODS:
Oxidative stress was assessed by thiobarbituric acid reactive species production, the Trolox-equivalent antioxidant capacity and plasma glutathione levels.RESULTS:
Thiobarbituric acid reactive species values were higher in patients without specific medication, followed by patients taking hydroxyurea and the Control Group (p < 0.0001). The antioxidant capacity was higher in patients taking hydroxyurea and lower in the Control Group (p = 0.0002 for Trolox-equivalent antioxidant capacity and p < 0.0292 for plasma glutathione). Thiobarbituric acid reactive species levels were correlated with higher hemoglobin S levels (r = 0.55; p = 0.0040) and lower hemoglobin F concentrations(r = -0.52; p = 0.0067). On the other hand, plasma glutathione levels were negatively correlated with hemoglobin S levels (r = -0.49; p = 0.0111) and positively associated with hemoglobin F values (r = 0.56; p = 0.0031).CONCLUSION:
Sickle cell anemia patients have high oxidative stress and, conversely, increased antioxidant activity. The increase in hemoglobin F levels provided by hydroxyurea and its antioxidant action may explain the reduction in lipid peroxidation and increased antioxidant defenses in these individuals.
Full text:
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Index:
LILACS (Americas)
Main subject:
Oxidative Stress
/
Hemoglobin SC Disease
/
Hydroxyurea
/
Anemia, Sickle Cell
Limits:
Adolescent
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto de Hematologia "Arthur de Siqueira Cavalcante"/BR
/
Santa Casa de São Paulo/BR
/
Universidade Estadual Paulista/BR
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