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Does rosmarinic acid underestimate as an experimental cardiovascular drug? / Seria o ácido rosmarínico subestimado como droga cardiovascular experimental?
Ferreira, Luciana Garros; Celotto, Andrea Carla; Capellini, Verena Kise; Albuquerque, Agnes Afrodite Sumarelli; Nadai, Tales Rubens de; Carvalho, Marco Tulio Menezes de; Evora, Paulo Roberto Barbosa.
  • Ferreira, Luciana Garros; University of São Paulo. Ribeirão Preto Faculty of Medicine. Department of Surgery and Anatomy. Postgraduate Program in Medical Surgical Clinic. Ribeirão Preto. BR
  • Celotto, Andrea Carla; University of São Paulo. Ribeirão Preto Faculty of Medicine. Department of Surgery and Anatomy. Postgraduate Program in Medical Surgical Clinic. Ribeirão Preto. BR
  • Capellini, Verena Kise; University of São Paulo. Ribeirão Preto Faculty of Medicine. Department of Surgery and Anatomy. Postgraduate Program in Medical Surgical Clinic. Ribeirão Preto. BR
  • Albuquerque, Agnes Afrodite Sumarelli; University of São Paulo. Ribeirão Preto Faculty of Medicine. Department of Surgery and Anatomy. Postgraduate Program in Medical Surgical Clinic. Ribeirão Preto. BR
  • Nadai, Tales Rubens de; University of São Paulo. Ribeirão Preto Faculty of Medicine. Department of Surgery and Anatomy. Postgraduate Program in Medical Surgical Clinic. Ribeirão Preto. BR
  • Carvalho, Marco Tulio Menezes de; University of São Paulo. Ribeirão Preto Faculty of Medicine. Department of Surgery and Anatomy. Postgraduate Program in Medical Surgical Clinic. Ribeirão Preto. BR
  • Evora, Paulo Roberto Barbosa; University of São Paulo. Ribeirão Preto Faculty of Medicine. Department of Surgery and Anatomy. Postgraduate Program in Medical Surgical Clinic. Ribeirão Preto. BR
Acta cir. bras ; 28(supl.1): 83-87, 2013. ilus
Article in English | LILACS | ID: lil-663898
ABSTRACT

PURPOSE:

The rationale of the present review is to analize the activity of Rosmarinus officinalis in the the cardiovascular system

METHODS:

A MEDLINE database search (from January 1970 to December 2011) using only rosmarinic acid as searched term.

RESULTS:

The references search revealed 509 references about rosmarinic acid in 40 years (the first reference is from 1970). There is a powerful prevalence of antioxidant and cancer studies. Other diseases are few cited, as inflammation, brain (Alzheimer and Parkinson disease) and, memory; allergy; diabetes; atherosclerosis, and; hypertension. It is necessary to consider the complete absence of studies on coronary artery disease, myocardial ischemia, heart failure or ischemia/reperfusion injury.

CONCLUSION:

Rosmarinic acid is underestimated as an experimental cardiovascular drug and deserves more attention.
RESUMO

OBJETIVO:

A justificativa da revisão é analisar a atividade de Rosmarinus officinalis no sistema cardiovascular

MÉTODOS:

Uma busca de banco de dados MEDLINE (de janeiro de 1970 a dezembro de 2011), utilizando apenas o ácido rosmarínico como termo pesquisado.

RESULTADOS:

A busca referências revelou 509 referências sobre o ácido rosmarínico em 40 anos (a primeira referência é de 1970). Há uma prevalência poderoso antioxidante e estudos do câncer. Outras doenças são citados alguns, como o cérebro, inflamação (de Alzheimer e doença de Parkinson) e, a memória, hipertensão, alergia, diabetes, aterosclerose, e. É necessário ter em conta a ausência completa de estudos sobre a doença de artéria coronária, isquemia do miocárdio, insuficiência cardíaca ou isquemia / lesão de reperfusão.

CONCLUSÃO:

O ácido rosmarínico é subestimado como uma droga experimental cardiovascular e merece mais atenção.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Cardiovascular Agents / Cardiovascular Diseases / Cinnamates / Depsides Type of study: Risk factors Limits: Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Cardiovascular Agents / Cardiovascular Diseases / Cinnamates / Depsides Type of study: Risk factors Limits: Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR