Efficacy evaluation of some antibiotics against syrian brucella spp isolates, in vitro
Braz. j. microbiol
;
43(4): 1269-1273, Oct.-Dec. 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-665808
ABSTRACT
Brucellosis is an endemic zoonosis in Syria, affecting large numbers of animals and there are an increasing number of cases in humans. The aim of this study is to investigate the in vitro efficacy of various traditional and new antibiotics against89 Brucella isolates (isolated from domestic animals) collected from different Syrian regions. Minimum inhibitory concentrations (MICs) of seventeen antibiotics were determined. Ciprofloxacin and ofloxacin were the most effective antibiotics, whereas sparfloxacin, levofloxacin, doxycycline and tetracycline had a moderate activity. In contrast, moxifloxacin and rifampicin had a low activity, while streptomycin, spiramycin and cephalosporines were ineffective. As a result, we come to the conclusion that a combination between one effective quinolone and doxycycline has a good efficacy against Brucella. Further in vivo studies are necessary to support this suggestion.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
In Vitro Techniques
/
Brucella
/
Drug Resistance, Microbial
/
Ciprofloxacin
/
Quinolones
/
Anti-Bacterial Agents
Type of study:
Evaluation studies
Limits:
Animals
/
Humans
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2012
Type:
Article
Affiliation country:
Syria
Institution/Affiliation country:
Atomic Energy Commission/SY
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