lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population
Biol. Res
;
45(4): 369-374, 2012. ilus
Article
in English
| LILACS
| ID: lil-668688
ABSTRACT
BACKGROUND:
Studies have demonstrated that some polymorphisms in different interleukin genes may increase the risk of cancer. The aim of this study was to investigate the association between the IL-8 (rs4073) -251A/T gene polymorphism and the risk of gastric cancer (GC). PATIENTS ANDMETHODS:
A case-control study was conducted on patients with noncardia gastric cancer. DNA was extracted from leukocytes and the IL-8 (rs4073) -251A/T polymorphism was analyzed by PCR-RFLP. Infection with Helicobacter pylori was investigated in the serum by ELISA.RESULTS:
The sample consisted of 104 patients with GC and 196 controls. Cigarette smoking (P=0.007) and high fat intake (P=0.01) were more frequent in patients with GC. The proportion of patients infected with H. pylori was similar in the two groups (P=0.101). The frequency of the genotype A/T was higher in the cancer group (P=0.008). An increased risk of GC was found in subjects carrying the genotype A/T (OR=2.50, CI 1.27-4.90), subjects with high fat intake (OR=1.92, CI 1.17-3.15), and smokers (OR=2.00, CI 1.203.31).CONCLUSIONS:
Subjects with the heterozygous A/T genotype, high fat intake and smokers or ex-smokers presented an increased risk of GC. Individuals with A/A genotype may have protective effect for GC.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Stomach Neoplasms
/
Genetic Predisposition to Disease
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2012
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Sao Paulo/BR
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