Influencia del estado nutricional, niveles hormonales séricos e historia familiar de cáncer en el desarrollo del cáncer de mama / Influence of nutritional status, hormones serum levels, and family history on breast cancer development
Rev. méd. Chile
;
140(10): 1263-1267, oct. 2012. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-668698
ABSTRACT
Background:
Several studies have analyzed the relation between obesity and the hormonal imbalances generated by overweight and a family history of breast cancer. All of these factors are potentially implicated in the early development of breast cancer.Aim:
To verify the existence of a significant relation between the nutritional status of breast cancer patients, their hormone serum levels (estrogens, prolactin, and progesterone), and the existence of a family history of breast cancer. Material andMethods:
Retrospective data was collected from clinical records of524 women diagnosed with breast cancer in a Spanish hospital.Results:
There was a positive association between estrogen, progesterone and prolactin serum levels and body mass index. The elevations in hormone levels occurred earlier in life among women with a family history of breast cancer. A two way ANOVA found a significant association between progesterone and prolactin levels with the age at diagnosis of breast cancer.Conclusions:
Extreme serum levels of these hormones appear to be related to the early development of breast cancer, which in turn is influenced by the existence of a family history of cancer among those women with normal or average hormone levels.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Progesterone
/
Prolactin
/
Breast Neoplasms
/
Nutritional Status
/
Estrogens
/
Obesity
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2012
Type:
Article
Affiliation country:
Spain
Institution/Affiliation country:
Universidad de Granada/ES
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