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Evaluation of hemodynamic effects of xenon in dogs undergoing hemorrhagic shock
Franceschi, Ruben C.; Malbouisson, Luiz; Yoshinaga, Eduardo; Auler Jr., Jose Otavio Costa; Figueiredo, Luiz Francisco Poli de; Carmona, Maria Jose C..
  • Franceschi, Ruben C.; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina. São Paulo. BR
  • Malbouisson, Luiz; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina. São Paulo. BR
  • Yoshinaga, Eduardo; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina. São Paulo. BR
  • Auler Jr., Jose Otavio Costa; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina. São Paulo. BR
  • Figueiredo, Luiz Francisco Poli de; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina. São Paulo. BR
  • Carmona, Maria Jose C.; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina. São Paulo. BR
Clinics ; 68(2): 231-238, 2013. ilus, tab
Article in English | LILACS | ID: lil-668812
ABSTRACT

OBJECTIVES:

The anesthetic gas xenon is reported to preserve hemodynamic stability during general anesthesia. However, the effects of the gas during shock are unclear. The objective of this study was to evaluate the effect of Xe on hemodynamic stability and tissue perfusion in a canine model of hemorrhagic shock.

METHOD:

Twenty-six dogs, mechanically ventilated with a fraction of inspired oxygen of 21% and anesthetized with etomidate and vecuronium, were randomized into Xenon (Xe; n = 13) or Control (C; n = 13) groups. Following hemodynamic monitoring, a pressure-driven shock was induced to reach an arterial pressure of 40 mmHg. Hemodynamic data and blood samples were collected prior to bleeding, immediately after bleeding and 5, 20 and 40 minutes following shock. The Xe group was treated with 79% Xe diluted in ambient air, inhaled for 20 minutes after shock.

RESULT:

The mean bleeding volume was 44 mL.kg-1 in the C group and 40 mL.kg-1 in the Xe group. Hemorrhage promoted a decrease in both the cardiac index (p<0.001) and mean arterial pressure (p<0.001). These changes were associated with an increase in lactate levels and worsening of oxygen transport variables in both groups (p<0.05). Inhalation of xenon did not cause further worsening of hemodynamics or tissue perfusion markers.

CONCLUSIONS:

Xenon did not alter hemodynamic stability or tissue perfusion in an experimentally controlled hemorrhagic shock model. However, further studies are necessary to validate this drug in other contexts.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Shock, Hemorrhagic / Xenon / Anesthetics, Inhalation / Models, Animal / Hemodynamics Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Shock, Hemorrhagic / Xenon / Anesthetics, Inhalation / Models, Animal / Hemodynamics Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR