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Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype
Izzo, Giselle; Forlenza, Orestes V.; Santos, Bernardo dos; Bertolucci, Paulo H. F.; Ojopi, Elida B.; Gattaz, Wagner F.; Kerr, Daniel Shikanai.
  • Izzo, Giselle; Universidade de São Paulo. Faculdade de Medicina. Department and Institute of Psychiatry. Laboratory of Neuroscience. São Paulo. BR
  • Forlenza, Orestes V.; Universidade de São Paulo. Faculdade de Medicina. Department and Institute of Psychiatry. Laboratory of Neuroscience. São Paulo. BR
  • Santos, Bernardo dos; Universidade de São Paulo. Faculdade de Medicina. Department and Institute of Psychiatry. Laboratory of Neuroscience. São Paulo. BR
  • Bertolucci, Paulo H. F.; Universidade de São Paulo. Faculdade de Medicina. Department and Institute of Psychiatry. Laboratory of Neuroscience. São Paulo. BR
  • Ojopi, Elida B.; Universidade de São Paulo. Faculdade de Medicina. Department and Institute of Psychiatry. Laboratory of Neuroscience. São Paulo. BR
  • Gattaz, Wagner F.; Universidade de São Paulo. Faculdade de Medicina. Department and Institute of Psychiatry. Laboratory of Neuroscience. São Paulo. BR
  • Kerr, Daniel Shikanai; Universidade de São Paulo. Faculdade de Medicina. Department and Institute of Psychiatry. Laboratory of Neuroscience. São Paulo. BR
Clinics ; 68(2): 277-280, 2013.
Article in English | LILACS | ID: lil-668817
ABSTRACT
In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele.
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Full text: Available Index: LILACS (Americas) Main subject: Membrane Transport Proteins / Nuclear Proteins / Polymorphism, Single Nucleotide / Cytoskeletal Proteins / LDL-Receptor Related Proteins / Adaptor Proteins, Signal Transducing / Alzheimer Disease Type of study: Etiology study Limits: Aged / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Membrane Transport Proteins / Nuclear Proteins / Polymorphism, Single Nucleotide / Cytoskeletal Proteins / LDL-Receptor Related Proteins / Adaptor Proteins, Signal Transducing / Alzheimer Disease Type of study: Etiology study Limits: Aged / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR