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Renal histopathllogical findings in dogs with visceral leishmaniasis / Achados histopatológicos renais em cães com leishmaniose visceral
Rigo, Rosangela Silva; Carvalho, Cristiano Marcelo Espínola; Honer, Michael Robin; Andrade, Gisele Braziliano de; Silva, Iandara Shetter; Rigo, Leonardo; Figueiredo, Helen Rezende; Barreto, Wanessa Teixeira Gomes.
  • Rigo, Rosangela Silva; lrigo@terra.com.br.
  • Carvalho, Cristiano Marcelo Espínola; lrigo@terra.com.br.
  • Honer, Michael Robin; lrigo@terra.com.br.
  • Andrade, Gisele Braziliano de; lrigo@terra.com.br.
  • Silva, Iandara Shetter; lrigo@terra.com.br.
  • Rigo, Leonardo; lrigo@terra.com.br.
  • Figueiredo, Helen Rezende; lrigo@terra.com.br.
  • Barreto, Wanessa Teixeira Gomes; lrigo@terra.com.br.
Rev. Inst. Med. Trop. Säo Paulo ; 55(2): 113-116, Mar-Apr/2013. tab, graf
Article in English | LILACS | ID: lil-668859
ABSTRACT

id="para1">Visceral leishmaniasis affects various organs including the kidneys; which can lead to renal failure and death. In order to verify this renal involvement, material was evaluated from 100 dogs naturally infected and with serological diagnosis of canine visceral leishmaniasis (CVL). Inflammatory changes were present in 25.3% of the tubules, in 67.0% of interstitium and in 52.0% of glomeruli. There was no significant difference (p > 0.05) between the presence of glomerulonephritis in symptomatic and oligosymptomatic dogs. The membranous and membranoproliferative glomerulonephritis were the most frequent, both with 18.0% frequency, followed by focal segmental glomerulosclerosis with 14.0%. Changes such as cylindruria, tubular and fibrosis hypertrophy, periglomerular inflammatory infiltrate, and multifocal and diffuse peritubular inflammatory infiltrate were observed. The findings are consistent with those of other authors indicating that renal involvement is common in CVL and the standards of membranous and membranoploriferative glomerulonephritis, as well as the tubulointerstitial involvement, are frequent.

RESUMO

id="para2">A leishmaniose visceral acomete vários órgãos entre eles os rins; o que pode levar a insuficiência renal e a morte. Com o objetivo de verificar este acometimento renal foram avaliados materiais de 100 cães naturalmente infectados e com diagnósticos sorológicos de leishmaniose visceral canina - LVC. As alterações inflamatórias estavam presentes em 25,3% dos túbulos, em 67,0% do interstício e em 52,0% dos glomérulos. Não houve diferença significativa (p > 0,05) entre a presença de glomerulonefrite em cães sintomáticos e oligossintomáticos. As glomerulonefrites membranosa e membrano proliferativa foram as mais freqüentes, ambas com 18,0% de freqüência seguidas da glomeruloesclerose segmentar e focal com 14,0%. Foram observadas alterações como cilindrúria, hipertrofia tubular e fibrose e infiltrados inflamatórios periglomerulares e peritubulares multifocais e difusos. Os achados concordam com os de outros autores indicando que o acometimento renal é comum na LVC e que os padrões de glomerulonefrites membranoploriferativa e membranosa; assim como o acometimento tubulointersticial são freqüentes.

Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Dog Diseases / Glomerulonephritis / Kidney / Leishmaniasis, Visceral Type of study: Diagnostic study / Practice guideline Limits: Animals Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 2013 Type: Article

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Full text: Available Index: LILACS (Americas) Main subject: Dog Diseases / Glomerulonephritis / Kidney / Leishmaniasis, Visceral Type of study: Diagnostic study / Practice guideline Limits: Animals Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 2013 Type: Article