Antifungal activity of raw extract and flavanons isolated from Piper ecuadorense from Ecuador
Rev. bras. farmacogn
;
23(2): 370-373, Mar.-Apr. 2013. ilus, tab
Article
in English
| LILACS
| ID: lil-669511
ABSTRACT
The MeOH extract of Piper ecuadorense Sodiro, Piperaceae, was chosen for metabolite isolation and elucidation due to the strong antifungal activity exhibited, measured by means of the broth microdilution method. Two known flavonoids pinostrobin (1) and pinocembrin (2) were isolated from 4.16 g. of dichloromethane extract by column chromatography, using a gradient of hexane/EtOAc. A total of 20 mg of 1 were obtained from the fraction eluted with hexane-EtOAc 955 v/v, and 100 mg of 2 were obtained from the fraction eluted with hexane-EtOAc 8515 v/v. The MIC values of the MeOH extract was 31.25 µg/mL for Trichophyton mentagrophytes ATCC® 28185 and 62.5 µg/mL for Trichophyton rubrum ATCC® 28188. The MIC value of pinocembrin was 125 µg/mL for Trichophyton mentagrophytes ATCC® 28185 and Trichophyton rubrum ATCC® 28188. Pinostrobin in antifungal test was not active against fungi tested.
Full text:
Available
Index:
LILACS (Americas)
Country/Region as subject:
South America
/
Ecuador
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Ecuador
Institution/Affiliation country:
Universidad Tecnica Particular de Loja/EC
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