Impact of HPV infection on the development of head and neck cancer
Braz. j. med. biol. res
;
46(3): 217-226, 15/mar. 2013. graf
Article
in English
| LILACS
| ID: lil-670893
ABSTRACT
Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to better understand the role of HPV in the development of these cancers. Although the proportion of HNSCC attributed to HPV varies considerably according to anatomical site, overall approximately 25% of all HNSCC are HPV-DNA positive, and HPV-16 is by far the most prevalent type. In this review we discuss the existing evidence for a causal association between HPV infection and HNSCC at diverse anatomical head and neck subsites.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Carcinoma, Squamous Cell
/
Papillomavirus Infections
/
Head and Neck Neoplasms
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2013
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto do Câncer do Estado de São Paulo/BR
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