Revisiting the Rich's formula: an update about granulomas in human tuberculosis
Braz. j. infect. dis
;
17(2): 234-238, Mar.-Apr. 2013.
Article
in English
| LILACS
| ID: lil-673203
ABSTRACT
The formula proposed by Rich in 1951 explained the formation in a tuberculous lesion in a period that was unknown cellular functions, cytokines and other immunological aspects involved in granuloma formation by tuberculosis; its components are assembled conceptually to explain the pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. In this manuscript, we report an update of Rich's formula based on the new and old concepts about pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. Current knowledge allows us to conclude that the balance between the characteristics of the bacillus and host protective response is necessary to indicate the outcome of pathogenesis, infection or active disease and the necrosis degree of the tuberculosis lesion.
Full text:
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Index:
LILACS (Americas)
Main subject:
Tuberculosis
/
Host-Pathogen Interactions
/
Mycobacterium tuberculosis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação José Silveira/BR
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