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Elevada frecuencia de enfermedad tiroidea funcional en embarazadas chilenas sin antecedentes de patología tiroidea utilizando el estándar de TSH internacional / Frequency of subclinical thyroid problems among women during the first trimester of pregnancy
Mosso M, Lorena; Martínez G, Alejandra; Rojas, María Paulina; Margozzini, Paula; Solari, Sandra; Lyng, Trinidad; Ortíz, Juan Andrés; Carvajal, Jorge.
  • Mosso M, Lorena; Hospital Sótero del Río. Departamento de Endocrinología. CL
  • Martínez G, Alejandra; Hospital Sótero del Río. Departamento de Endocrinología. CL
  • Rojas, María Paulina; Hospital Sótero del Río. Departamento de Endocrinología. CL
  • Margozzini, Paula; Hospital Sótero del Río. Departamento de Endocrinología. CL
  • Solari, Sandra; Hospital Sótero del Río. Departamento de Endocrinología. CL
  • Lyng, Trinidad; Hospital Sótero del Río. Departamento de Endocrinología. CL
  • Ortíz, Juan Andrés; Hospital Sótero del Río. Departamento de Endocrinología. CL
  • Carvajal, Jorge; Hospital Sótero del Río. Departamento de Endocrinología. CL
Rev. méd. Chile ; 140(11): 1401-1408, nov. 2012. ilus, graf, tab
Article in Spanish | LILACS | ID: lil-674005
ABSTRACT

Background:

Thyroid hormones play an important role in fetal neural and cognitive development. Therefore thyroid abnormalities should be detected and treated early during pregnancy.

Aim:

To assess the frequency and risk factors for functional thyroid disorders during the first trimester of pregnancy. Material and

Methods:

A blood sample was obtained from women during their first trimester of pregnancy, consulting in a prenatal care facility. Women with known thyroid diseases were excluded from the study. Thyroid stimulating hormone (TSH), total thyroxine (T4) and free thyroxine (fT4) were measured by electrochemoluminiscence. Antithyroid peroxidase antibodies (anti TPO) were measured by enzyme immunoassay.

Results:

Five hundred and ten women aged 25.7 ± 6.6 years were assessed. The frequency of clinical hypothyroidism was 0.6%, subclinical hypothyroidism 35.3% and clinical hyperthyroidism 1%. Five percent of women with hypothyroidism and 3.5% of euthyroid women had positive anti TPO antibodies. There was no association between the frequency of thyroid diseases and risk factors for thyroid diseases.

Conclusions:

There is a high frequency of subclinical thyroid diseases among women consulting in this prenatal care clinic.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications / Hypothyroidism Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Pregnancy Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2012 Type: Article / Project document Affiliation country: Chile Institution/Affiliation country: Hospital Sótero del Río/CL

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Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications / Hypothyroidism Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Pregnancy Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2012 Type: Article / Project document Affiliation country: Chile Institution/Affiliation country: Hospital Sótero del Río/CL