Biochemical study of the effects of cilostazol in rats subjected to acute ischemia and reperfusion of hind limbs
Acta cir. bras
;
28(5): 361-366, May 2013. tab
Article
in English
| LILACS
| ID: lil-674156
ABSTRACT
PURPOSE:
To investigate whether cilostazol has a protective effect on acute ischemia and reperfusion of hind limbs of rats through study of biochemical variables in blood and urine.METHODS:
Forty six animals were randomized and divided into two groups. Group I received a solution of cilostazol (10 mg/Kg) and group II received saline solution 0.9% (SS) by orogastric tube after ligature of the abdominal aorta. After four hours of ischemia the animals were divided into four subgroups group IA (Cilostazol) two hours of reperfusion. Group IIA (SS) two hours of reperfusion. Group IB (Cilostazol) six hours of reperfusion. Group IIB (SS) six hours of reperfusion. After the reperfusion period, was held to collect urine and blood for biochemical measurements. The biochemical parameters studied were urea, creatinine, sodium, potassium and myoglobin in blood and urea, creatinine, myoglobin in urine.RESULTS:
There was no statistically significant difference between groups.CONCLUSION:
Cilostazol had no protective effect on ischemic acute reperfusion of hind limbs of rats in this model.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tetrazoles
/
Platelet Aggregation Inhibitors
/
Reperfusion Injury
/
Hindlimb
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2013
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UMC/BR
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