The diagnostic significance of NT-proBNP and troponin I in emergency department patients presenting with palpitations
Clinics
;
68(4): 543-547, abr. 2013. tab, graf
Article
in English
| LILACS
| ID: lil-674230
ABSTRACT
OBJECTIVE:
This prospective study investigated the diagnostic significance of the N-terminal pro-brain natriuretic (NT-proBNP) and troponin I peptides in emergency department patients presenting with palpitations.METHODS:
Two groups of patients with palpitations but without documented supraventricular tachycardia were compared a group with supraventricular tachycardia (n = 49) and a control group (n = 47). Both groups were diagnosed using electrophysiological studies during the study period. Blood samples were obtained from all of the patients to determine the NT-proBNP and troponin I levels within the first hour following arrival in the emergency department.RESULT:
The mean NT-proBNP levels were 207.74±197.11 in supraventricular tachyarrhythmia group and 39.99±32.83 pg/mL in control group (p<0.001). To predict supraventricular tachycardia, the optimum NT-proBNP threshold was 61.15 pg/mL, as defined by the receiver operating characteristic (ROC) curve, with a non-significant area under the ROC curve of 0.920 (95% CI, 0.86-0.97, p<0.001). The NT-proBNP cut-off for diagnosing supraventricular tachycardia had 81.6% sensitivity and 91.5% specificity. Supraventricular tachycardia was significantly more frequent in the patients with NT-proBNP levels ≥61.15 pg/mL (n = 44, 90.9%, p>0.001). The mean troponin I levels were 0.17±0.56 and 0.01±0.06 pg/mL for the patients with and without supraventricular tachycardia, respectively (p<0.05). Of the 96 patients, 21 (21.87%) had troponin I levels ≥0.01 2 (4.25%) in the control group and 19 (38.77%) in the supraventricular tachycardia group (p<0.001).CONCLUSION:
Troponin I and, in particular, NT-proBNP peptide were helpful for differentiating supraventricular tachycardia from non- supraventricular tachycardia palpitations. Further randomized, large, multicenter trials are needed to define the benefit and diagnostic ...
Full text:
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Index:
LILACS (Americas)
Main subject:
Peptide Fragments
/
Tachycardia, Supraventricular
/
Troponin I
/
Natriuretic Peptide, Brain
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2013
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Abant Izzet Baysal University/TR
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